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Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

机译：双pI3K / mTOR抑制剂pF-04691502在来源于携带pIK3Ca突变的结肠直肠癌干细胞的人异种移植肿瘤模型中的抗肿瘤效力。

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Douglas D Fang; Cathy C Zhang; Yin Gu; Jitesh P Jani; Joan Cao; Konstantinos Tsaparikos; Jing Yuan; Melissa Thiel; Amy Jackson-Fisher; Qing Zong; Patrick B Lappin; Tomoko Hayashi; Richard B Schwab; Anthony Wong; Annette John-Baptiste; Shubha Bagrodia; Geritt Los; Steve Bender; James Christensen; Todd Vanarsdale;
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1. PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer [J] . HerzogA., BianY., BroekR.V., Clinical cancer research: an official journal of the American Association for Cancer Research . 2013,第14期

机译：PI3K / mTOR抑制剂PF-04691502诱导人头颈癌异种移植和小鼠基因敲除模型中的野生型TP53可增强抗肿瘤活性
2. Activation of WNT/beta-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations [J] . Park Ye-Lim, Kim Hwang-Phill, Cho Young-Won, International Journal of Cancer =: Journal International du Cancer . 2019,第2期

机译：激活WNT /β-连环蛋白信号传导导致含PIK3CA突变的结肠直肠癌细胞中双PI3K / MTOR抑制剂的抗性
3. Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells [J] . MartinelliE., TroianiT., DAiutoE., International Journal of Cancer =: Journal International du Cancer . 2013,第9期

机译：pimasertib（一种选择性的MEK 1/2抑制剂）与PI3K / mTOR抑制剂或多靶点激酶抑制剂联合在耐pimasertib的人肺癌和大肠癌细胞中的抗肿瘤活性
4. 3D Engineered Patient-Derived Xenograft Tumors to Recapitulate the Obese Colorectal Cancer Tumor Microenvironment [C] . Iman Hassani, Benjamin Anbiah, Bulbul Ahmed, Society for Biomaterials annual meeting and exposition . 2019

机译：3D工程化的患者衍生异种移植肿瘤，概述了肥胖结直肠癌肿瘤的微环境
5. Dual PI3K/mTOR inhibition with BEZ235 augments the therapeutic efficacy of doxorubicin in cancer without influencing cardiac function. [D] . Durrant, David Ellis. 2015

机译：BEZ235对PI3K / mTOR的双重抑制作用增强了阿霉素在癌症中的治疗效果，而不会影响心脏功能。
6. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation [O] . Douglas D. Fang, Cathy C. Zhang, Yin Gu, -1

机译：PI3K / mTOR双重抑制剂PF-04691502在具有PIK3CA突变的结直肠癌干细胞衍生的人异种移植肿瘤模型中的抗肿瘤功效。
7. Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells [O] . Martinelli Erika, Troiani Teresa, DAiuto Elena, 2013

机译：pimasertib（一种选择性的MEK 1/2抑制剂）与PI3K / mTOR抑制剂或多靶点激酶抑制剂联合在耐pimasertib的人肺癌和大肠癌细胞中的抗肿瘤活性

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

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